系統介紹

動物精細行為分析系統是Gene&I聯合Cleversys推出的針對于復雜疾病表現進行分析的展品，也是動物行為分析的旗艦產品，代表了動物行為分析的行業領先水平。

產品可自動分析動物日常行為的23種身體行為，并可將分析的行為進行分類統計。針對于帕金森、神經性舞蹈癥、阿爾茲海默癥、瘋牛病等一些無法使用單一指標進行評價的疾病，可通過對動物某一些身體行為異常改變的統計分析來進行評價。

產品具有兩個版本。HomecageScan(CleverSys, Inc., CSI)是針對于大小鼠日常行為分析的版本；PrimateScan(CleverSys, Inc., CSI)是針對于靈長類動物進行日常行為分析的版本。

可分析動物直立身體、回降身體、向左走、向右走、吃、喝、咀嚼、清理身體、排尿、垂直懸吊、偎著籠子懸吊、垂直降落、跳躍、轉動、轉圈、睡覺、痙攣、覺醒、 挖掘找尋糧食、嗅、聞、間歇停頓 、伸懶腰等行為。

系統特點

●  全自動動物精細自然行為分析

●  晝夜節律分析

●  實時分析和回放分析兩種選擇

●  24小時以上連續攝像

●  具有雙擊活動事件進行事件發生視頻片段回放功能

●  實驗過程中動物行為詳細的統計信息

系統特點

●  生物節律

●  神經性舞蹈癥(Huntington Disease)

●  Prion Disease

●  狂躁癥(Mania)

●  疾病過程觀察

●  遺傳研究

●  毒理學研究

●  進食/飲水研究

●  肥胖/代謝疾病研究

●  慢性/自發疼痛研究

●  運動缺陷研究

●  衰老研究

Phenotypic arrays of HD and PrD behaviors over time. Meanvalues for HD(A) or PrD (B) were divided by mean control values to give the fold increase or decrease in the behaviors listed. The fold increase or decrease is indicated in the figure as increasing intensity of blue for negative fold changes or yellow for positive fold changes

Andrew D. Steele, Walker S. Jackson, Oliver D. King, and Susan Lindquist. The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. 

Reference

E.B. Adamah-Biassi, I. Stepien, R.L. Hudson, M.L. Dubocovich (2013), Automated Video Analysis System Reveals Distinct Diurnal Behaviors in C57BL/6 and C3H/HeN Mice, Behavioural Brain Research, Volume 243, 15 April 2013, Pages 306–312.

Miki Hiasa, Yumiko Isoda, Yasushi Kishimoto, Kenta Saitoh, Yasuaki Kimura, Motomu Kana, MasakatsuShibasaki, Dai Hatakeyama, Yutaka Kirino, Takashi Kuzuhara, (2013), Inhibition of monoamine oxidase A and stimulation of behavioural activities in mice by the inactive prodrug form of the anti-influenza agent oseltamivir, British Journal of Pharmacology, 2013.

Kyzar, M Pham, A Roth, J Cachat, J Green, S Gaikwad, and AV Kalueff, (2012) Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: The utility of behavior-recognition tools to characterize mutant mouse phenotypes, Brain Res Bull, Dec 2012; 89(5-6): 168-76.

NC Lee, YD Shieh, YH Chien, KY Tzen, I Yu, PW Chen, (2012) Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency, Neurobiology of Disease, Available online 26 December 2012.

Yasushi Kishimoto, ErinaHigashihara,AkikoFukuta, Akira Nagao, Yutaka Kirino, (2012) Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease, Brain Research, Available online 7 November 2012.

Gillian Hamilton and Thomas H. Gillingwater, (2012) Spinal muscular atrophy: going beyond the motor neuron, TRMOME-835; No. of Pages 11.

TopScan

動物常規實驗行為分析系統

DepressionScan

動物抑郁行為分析系統

GaitScan

動物步態分析系統

FreezeScan

動物恐懼實驗分析系統

AquaScan

斑馬魚行為自動分析系統

HomecageScan

自然精細行為分析系統

SocialScan

動物社交行為分析系統

DrugeffectScan

動物刻板行為分析系統

SeizureScan

動物癲癇行為分析系統